| InFamous Platinum | Collect all trophies. | Platinum |
| Hard Finish | Finish story mode on Hard, without changing the difficulty setting. | Gold |
| Good Finish | Beat the game as a Hero. | Silver |
| Evil Finish | Beat the game while Infamous. | Silver |
| Community Organizer | Take over all territory in the Neon District. | Silver |
| Civic Leader | Take over all territory in the Warren. | Silver |
| Urban Designer | Take over all territory in the Historic District. | Silver |
| Evil to the Core | BBB | Silver |
| True Hero | Purchase every negative Karma upgrade for each power. | Silver |
| Goody Two Shoes | Reach full positive Karma. | Silver |
| Truly Infamous | Reach full negative Karma. | Silver |
| Stunt Master | Complete all of the stunts on the stunt list. | Silver |
| Just Scratched the Surface | Collect all Dead Drops in the Neon District. | Bronze |
| Further Down the Rabbit Hole | Collect all Dead Drops in the Warren. | Bronze |
| You're so Sly | Collect all Dead Drops in the Historic District. | Bronze |
| Junior Geologist | Find 25% of the Shards. | Bronze |
| Member of the Mineral Club | Find 50% of the Shards. | Bronze |
| Rockhound | Find 100% of the Shards. | Bronze |
| Frequent Flyer | Travel 5 kilometers using Static Thrusters. | Bronze |
| Hotfoot | Travel 25 kilometers while riding the rails. | Bronze |
| Electric Hobo | Ride the train for 2 kilometers. | Bronze |
| Casey Jones | Take down 25 enemies while riding on a moving train. | Bronze |
| Road Kill | Take down 25 enemies while riding on the roof of a moving vehicle. | Bronze |
| Drop Everything | Thunder Drop for a total distance of at least 500 meters. | Bronze |
| AC/DC | Drain 750 megawatts of power from Empire City. | Bronze |
| Get Off My Cloud | Get 100 High Fall take downs. | Bronze |
| Red Baron | Take down 100 enemies while they are airborne. | Bronze |
| Fish in a Barrel | Kill 50 enemies by using water. | Bronze |
| True Potential | Purchase every upgrade for a single power. | Bronze |
| Oh, You've Done This Before | Take down 50 enemies by sticking them with a grenade. | Bronze |
| The Hunger | Bio Leech 100 enemies. | Bronze |
| Doctor Cole | Heal 250 pedestrians. | Bronze |
| Good Eats | Good guys feed the needy. | Bronze |
| Evil Eats | Bad guys never share their food. | Bronze |
| Good Riot | Good guys stand up and take the heat. | Bronze |
| Evil Riot | Bad guys love starting riots. | Bronze |
| Good Train | Good guys pro-actively facilitate transportation solutions. | Bronze |
| Evil Train | Bad guys make it clear who the boss is. | Bronze |
| Good Exposure | Good guys are heroes to others. | Bronze |
| Evil Exposure | Bad guys love to be seen. | Bronze |
| Good Sphere | Good guys put a stop to the madness. | Bronze |
| Evil Sphere | Bad guys always want more power. | Bronze |
| Good Intentions | Good guys work for the greater good. | Bronze |
| Evil Intentions | Bad guys can't say goodbye. | Bronze |
| Stunt Man | Complete any one stunt from the stunt list. | Bronze |
| Stunt Coordinator | Complete 10 of the stunts on the stunt list. | Bronze |
